Japanese Researchers Regrow Functional Joints In Frogs: Breakthrough Could Lead To Regeneration Of Amputated Limbs


For the first time, Japanese scientists successfully regenerated functional joints in frogs – a breakthrough that may pave the way for functional joint regeneration in humans and other mammals in the future.

A team of researchers from Kyoto University hopes to apply this newly discovered “reintegration” technique in helping transplanted tissues integrates with original limbs and organs following amputation or surgery.

The researchers published their findings in the journal Regeneration.

Some animals – newts, for example – can regenerate a smaller yet fully functioning limb once the original part has been detached. Frogs are deemed to be the middle ground between these animals and mammals incapable of regenerating their limbs.

Frogs regrow “spikes” or cartilage rods that protrude from affected areas – new cartilage limbs that do not have joints and therefore are incapable of bending at will.

In order to be functional, joints need to integrate multiple tissues, namely two opposing skeletons for an interlocking system and muscles that insert into those skeletal tissues. Frogs do not have this tissue-reconnecting ability.

What then is the mechanism that the Japanese team dubbed “reintegration”?

Read More: Techtimes

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