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Friday, March 17, 2017

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Scientist Discovered a Way to Locate AIDs Virus Hideout

Oyetoke Tobi - Friday, March 17, 2017

French scientists made a declaration on March 15, that they had discovered a method to identify tricky white blood cells, which provides a hiding spot for the HIV-1 virus in humans eating away anti-HIV medications due to AIDS.

These sources of cells would possibly be the most significant factor to eradicate AIDS and the human immunodeficiency virus (HIV) which causes the condition.

The research helped to find a way to understand the virus reservoirs better as revealed by France's CNRS research institute, which took part in the study. He also added that sooner or later, the discovery should help to produce remedial approaches to wipe out the dormant virus.  

Why HIV Does Not Have a Cure
No cure has been found or invented for HIV and those suffering from HIV need to be using the virus-suppressing medications all 
through their lives.

The reason for this problem is the limited and inadequate number of immune system cells that are in a category of cells known as CD4 T lymphocytes which provides shelter to the lethal virus. It lets the virus develop and spread all over the body.

The researchers used the blood of several HIV patients and studied them by using a in vitro model during the research.
They discovered a protein which was not present in healthy cells, duplicated "CD32a" on the external area of the reservoir cells affected by the virus.

Douglas Richman, AIDS researcher from the University of California San Diego, mentioned that these kinds of signs are very hard to spot.

An HIV infected human being has close to 200 billion CD4 T cells among which the number of virus reservoirs is only one in a million.

5 liters of blood contains two percent of the body's CD4 T cells in an adult human, said Richman. So, 80 million CD4 T cells would be found in about a 100 milliliter blood sample and among those 80 million and only about 80 would be virus reservoirs.

However, there is some assumption whether CD32a aggressively supports the deadly virus to hide in CD4 cells or not. If the answer is yes, then it is likely possible to target medications and stop the stealthy process.

According to the proposal of Richman, CD32a is very rare to find and only about half CD4 T reservoir cells contain it. However, to get rid of the dormant HIV, a much larger amount of the CD32a would be needed.

He also added that, additional study needs to be carried out in order to find out whether CD32a is suitable for the CD4 T cells in the bone marrow, lymph nodes, gut and several other tissues which can be regarded as reservoirs.



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